GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs1577917 | 1 | rs36096931 | chr6:86693134 | SNHG5 | chr6:86386726-86388451:- | -0.42 | -4.96 | 1.9E-6 | Response to antipsychotic treatment |
| UCEC | cis | rs60843830 | 1 | rs36216559 | chr2:262335 | SH3YL1 | chr2:218138-264810:- | -0.49 | -6.69 | 3.99E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs9309473 | 1 | rs3738848 | chr2:73761881 | ALMS1P | chr2:73872046-73912692:+ | 0.52 | 6.16 | 6.08E-9 | Metabolite levels |
| UCEC | cis | rs8010715 | 1 | rs3742500 | chr14:24611978 | FAM158A | chr14:24608175-24610797:- | -0.47 | -8.34 | 4.21E-14 | IgG glycosylation |
| UCEC | cis | rs7528684 | 1 | rs3761959 | chr1:157669278 | FCRL3 | chr1:157646278-157670775:- | 0.39 | 6.6 | 6.59E-10 | Type 1 diabetes autoantibodies |
| UCEC | cis | rs2241437 | 1 | rs3770087 | chr2:86267068 | LOC90784 | chr2:86247339-86250991:- | -0.69 | -6.44 | 1.51E-9 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| UCEC | cis | rs2241437 | 1 | rs3770090 | chr2:86263288 | LOC90784 | chr2:86247339-86250991:- | -0.69 | -6.44 | 1.51E-9 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| UCEC | cis | rs703842 | 1 | rs3782130 | chr12:58161898 | TSFM | chr12:58176536-58191367:+ | -0.41 | -4.45 | 1.66E-5 | Multiple sclerosis |
| UCEC | cis | rs6542095 | 1 | rs3783521 | chr2:113543577 | PSD4 | chr2:113931560-113960676:+ | -0.47 | -4.4 | 1.99E-5 | Endometriosis |
| UCEC | cis | rs6542095 | 1 | rs3783526 | chr2:113541807 | PSD4 | chr2:113931560-113960676:+ | 0.47 | 4.4 | 1.99E-5 | Endometriosis |
| UCEC | cis | rs60843830 | 1 | rs3791220 | chr2:227066 | SH3YL1 | chr2:218138-264810:- | -0.48 | -6.44 | 1.47E-9 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs60843830 | 1 | rs3791221 | chr2:226933 | SH3YL1 | chr2:218138-264810:- | -0.48 | -6.39 | 1.9E-9 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs60843830 | 1 | rs3791223 | chr2:222336 | SH3YL1 | chr2:218138-264810:- | -0.49 | -6.64 | 5.23E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs60843830 | 1 | rs3791224 | chr2:221981 | SH3YL1 | chr2:218138-264810:- | -0.47 | -6.56 | 8.1E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs2130392 | 1 | rs3796689 | chr4:185649866 | MLF1IP | chr4:185615220-185655286:- | -0.42 | -5.77 | 4.21E-8 | Kawasaki disease |